Table 2. Univariate and multivariate Cox regression models.

Group	Univariate analysis			Multivariate analysis*			Multivariate analysis after multiple imputation*
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
No WRF/more reduction	1 (reference)			1 (reference)			1 (reference)
No WRF/less reduction	1.83	1.29–2.56	<0.001	1.61	1.10–2.37	0.014	1.15	0.90–1.47	0.264
WRF/more reduction	0.84	0.38–1.87	0.683	0.77	0.34–1.75	0.537	1.00	0.64–1.58	0.986
WRF/less reduction	4.50	2.78–7.28	<0.001	3.34	1.95–5.73	<0.001	2.15	1.53–3.02	<0.001

*Adjustment was performed for age, gender, New York Heart Association functional class, systolic blood pressure, heart rate, history of heart failure, history of diabetes, left ventricular ejection fraction, prescription of beta blocker, prescription of angiotensin inhibitor or angiotensin II receptor blocker at admission, hemoglobin, serum sodium, serum creatinine, blood urea nitrogen (BUN) and BNP at baseline, as well as C-reactive protein.