Table 2. Comparison of cell scores between peripheral blood mononuclear cells (PBMCs) and Tempus samples.
| Cell type | Number of defining genes (not detected) | Score PBMCs, median (IQR) | Score Tempus, median (IQR) | Adjusted P-value |
|---|---|---|---|---|
| NK CD56dim cells | 2 | 5.71 (5.25–6.27) | 5.61 (5.26–6.10) | 0.633 |
| Cytotoxic cells | 9 | 9.54 (9.27–9.86) | 9.14 (8.39–9.44) | 0.024 |
| Dendritic cells | 3 (PBMC: 3, Tempus: 2) | 3.54 (3.34–3.89) | 4.65 (4.14–5.06) | <0.001 |
| Regulatory T cells | 1 | 5.08 (4.65–5.75) | 5.06 (4.74–5.50) | 0.675 |
| CD45+ cells | 1 | 10.69 (10.48–11.14) | 13.26 (12.93–13.71) | <0.001 |
| Macrophages | 2 | 9.10 (8.58–9.43) | 8.53 (8.34–8.70) | 0.009 |
| T cells | 5 | 8.11 (7.97–8.76) | 7.95 (7.55–8.41) | 0.136 |
| Mast cells | 2 (PBMC: 1) | 4.47 (4.16–5.18) | 5.81 (5.51–6.05) | <0.001 |
| Neutrophils | 2 | 11.85 (11.12–12.46) | 14.38 (12.82–15.09) | <0.001 |
| Natural killer cells | 2 | 6.52 (6.30–7.34) | 7.28 (6.79–7.44) | 0.022 |
| Exhausted CD8+ cells | 2 | 6.40 (6.02–6.61) | 6.36 (6.13–6.71) | 0.633 |
| B cells | 3 | 7.72 (7.11–8.33) | 6.64 (6.37–6.92) | <0.001 |
| Th1 cells | 1 | 8.05 (7.64–8.48) | 8.19 (7.81–5.78) | 0.548 |
| CD8+ T cells | 2 | 7.96 (7.34–8.40) | 6.55 (6.12–7.07) | <0.001 |
Data are presented as log2 values. P-values are calculated with Mann-Whitney U tests and adjusted with Benjamin-Hochberg procedure. IQR = interquartile range, Th = T-helper.