Table 1.
Diagnostic Criteria for Markers of Colorectal Cancer
| Group/Markers | Diagnostic Sensitivity (%) | Diagnostic Specificity (%) | Area under ROC Curve |
|---|---|---|---|
| Tumor antigens | |||
| Carcinoembryonic antigen CEA10,22 | 64 | 90 | 0.7940 |
| Carbohydrate antigen CA 19–915 | 34 | 55 | 0.6520 |
| Tissue polypeptide specific antigen TPS16 | 95 | 83 | 0.8020 |
| Tumor-associated glycoprotein-72 TAG-7219 | 40 | 77 | No data |
| Hematopoietic growth factors (HGFs) | |||
| Stem cell factor (SCF)24 | 89 | 17 | 0.7232 |
| Granulocyte-colony stimulating factor (G-CSF)21 | 31 | 95 | 0.6900 |
| Macrophage-colony stimulating factor (M-CSF)21 | 65 | 95 | 0.8300 |
| Interleukin622 | 72 | 96 | 0.8960 |
| Interleukin324 | 55 | 80 | 0.6840 |
| Enzymes | |||
| Alcohol dehydrogenase (ADH)27 | 60 | 70 | 0.6538 |
| Isoenzyme class I of ADH27 | 76 | 82 | 0.7231 |
| N-acetyl-β-D-hexosaminidase (HEX) in serum28 | 90 | 95 | 0.9326 |
| N-acetyl-β-D-hexosaminidase (HEX) in urine28 | 86 | 81 | 0.8739 |
| CathepsinD31 | 91 | 93 | 0.9137 |
| Ornithine decarboxylase (ODC)35 | 82 | 85 | No data |
| Circulating tumor cells | |||
| Cytokeratin 20 (CK20)39 | No data | No data 56 | No data |
| Multidrug resistance-related proteins (MRPs)41 | No data | No data | No data |