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. 2020 May 19;48(W1):W218–W229. doi: 10.1093/nar/gkaa395

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — RPF metagene distribution from RiboToolkit analysis indicates that mRNA translation is globally impacted in mouse 3T3 fibroblast cells in response to acute heat shock. (A) RFP metagene distribution plots (whole CDS and regions around translation start/end sites) comparing cells that experienced chronic heat stress (42°C for 8 h, HS8M) and control cells. (B) RFP metagene distribution plots comparing cells that experienced acute heat stress (44°C for 2 h, HS2S) and control cells. (C) Numerous individual mRNAs with sufficient RPF coverage showed a similar distribution to the RPF metagene plot, such as Vim and Serpine1. (D) There are exceptions where some genes escape from the global elongation and initiation blocks, such as Atf4 and Atf5, which were translationally up-regulated via translation of uORFs.