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. 2020 Jun 4;48(W1):W185–W192. doi: 10.1093/nar/gkaa420

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Analysis of sequence variations from TCGA-IB-7651. (A) Variant filtering method applied for the analysis of queried variants. Nonsynonymous SNVs were identified and prioritized according to their oncogenic classifications and targetable potential. (B) Several nonsynonymous variants were identified as potential biomarkers of response to targeted therapies for PDAC, including PARP inhibition and platinum-based chemotherapies. Pathways analyses of these variants identified enrichments within DNA damage repair (DDR) processes, including (C) DNA double-strand break response and (D) base excision repair. Please, refer to https://www.snp-nexus.org/v4/results/nar2020/ to have a better look of these figures and explore the results for the Case Study.