Table 1.
Overview of current bioinformatics tools for Acr research
| Name | Resource provided | Features | Input | Output |
|---|---|---|---|---|
| anti-CRISPRDB | Database | Experimentally characterized Acrs and their homologs and BLAST search | NA | NA |
| CRISPRminer | Database | Experimentally characterized Acrs and their homologs and genomic context | NA | NA |
| Acr nomenclature | Google spreadsheets | Experimentally characterized Acrs and Acas nomenclature | NA | NA |
| Self-Targeting Spacer Searcher | Standalone package | Workflow for self-targeting spacer identification | List of genomes | Self-targeting spacers |
| AcrCatalog | Database | Predicted Acrs from decision tree ML classifier + heuristic filtering | NA | NA |
| AcRanker | Web server and standalone package | XGBoost ML classifier using AA biases | Protein sequences | Ranked protein list (no Acr subtype) |
| AcrFinder | Web server and standalone package | Workflow combining Homology + GBA + Self-targeting and user-friendly website | Protein or DNA sequences | Acr-Aca operons (with Acr subtype) |