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. 2020 Jun 26;477(12):2401–2419. doi: 10.1042/BCJ20200368

Figure 1. Antitoxin AbiEi is a two-domain protein with bilateral opposingly charged faces.

Figure 1.

(A) Scaled representation of the four M. tuberculosis TA systems containing NTase-like toxin genes and AbiE from S. agalactiae. Numbers in parentheses indicate amino acid length. All five toxins are DUF1814 proteins; Rv1044, Rv2827c and AbiEi are COG5340-containing antitoxins. Putative antitoxin Rv0837c is a COG4861 protein and the significantly shorter putative antitoxin Rv0078B is unclassified. The four M. tuberculosis systems were re-named as shown. (B) AbiEi antitoxin structure shown in pink cartoon representation, in two views rotated 180°. (C) Electrostatic potential of AbiEi, posed as per (B), with electropositive charge in blue and electronegative charge in red. (D) Previously solved Rv2827c structure shown in blue cartoon representation, in two views rotated 180° (PDB: 1ZEL). (E) Electrostatic potential of Rv2827c, posed as per (D), colored as per (C).