Table 3. Multivariable logistic regression analysis of predictive factors of vaccine responses to Env and Gag/Pol/Nef, EV03/ANRS VAC20 Phase I/II Trial.
| Univariable models | Multivariable model | |||||
|---|---|---|---|---|---|---|
| Factor | Odds Ratio | 95%CI | p | Odds Ratio | 95%CI | p |
| 3 DNA vs 2 DNA | 2.1 | 1.0–4.5 | 0.048 | 2.3 | 1.0–5.0 | 0.042 |
| Female vs male | 0.8 | 0.4–1.7 | 0.62 | 0.7 | 0.3–1.6 | 0.38 |
| Age (per 10 years older) ¶ | 0.6 | 0.4–0.9 | 0.011 | 0.5 | 0.3–0.9 | 0.010 |
| Geographical region (France vs other) | 0.6 | 0.3–1.3 | 0.20 | 1.1 | 0.4–2.8 | 0.84 |
| Vaccinia antibodies* | ||||||
| Binding Abs | 0.9 | 0.4–1.9 | 0.78 | 1.3 | 0.5–3.0 | 0.60 |
| Neutralizing Abs | 1.4 | 0.6–3.2 | 0.44 | 2.1 | 0.8–5.5 | 0.14 |
Note
¶ linear association
* Results shown are for antibodies present versus not present; there also was no influence of antibody titre.