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. 2020 Jun 26;156:107–112. doi: 10.1016/j.freeradbiomed.2020.06.032

Table 1.

Ebselen action on various viruses as discussed in the text.

Virus Target of ebselen Effect of ebselen Reference
SARS-CoV-2 Main corona virus protease (Mpro) Inhibition of viral replication [1]
Human immunodeficiency virus type 1 (HIV-1)
Lens-epithelium-derived growth-factor (LEDGF/p75) binding to HIV-1 integrase Inhibition of viral integration into host cell DNA [35]
Thioredoxin reductase-1 (TR-1) down-regulation of HIV-1 encoded transcriptional activator, Tat, in macrophages Inhibition of TR-1 to facilitate HIV-1 replication [36]
Capsid protein Inhibition of viral capsid core assembly [34]
Hepatitis C virus (HCV) Non-structural protein 3 (NS3) Inhibition of NS3 helicase activity and virus replication [40]
Influenza A virus HKx31 (H3N2) infection in mice with cigarette smoke-induced lung injury Possibly H3N2 virus and inflammatory mediators Lowered viral titer, BALF leukocyte count, and lung inflammatory cytokines and protease expression [55]