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. 2020 Jun 24;8(1):e000958. doi: 10.1136/jitc-2020-000958

Figure 2.

Figure 2

The immunophenotypic characteristics of immune checkpoint inhibitor-associated duodenitis (ICI-Duo) and ICI-celiac disease (CeD) were assessed and quantified in comparison to CeD and normal duodenum. (A) Number of intraepithelial lymphocytes expressed as an average number of CD3, CD8, and δγ positive cells per 100 enterocytes in three well-oriented villi. (B) Number of lamina propria lymphocytes reported as an average number of CD3 and CD8 cells per high power field (HPF; 400×) in three HPFs. (C) Percentage of lamina propria surface area infiltrated by positive cells in the biopsy stained for CD68, programmed death ligand 1 (PD-L1), and programmed death 1 (PD-1). The p value was calculated by the Student t-test and the Welch’s t test for unequal variance, as appropriate. *P<0.05. **P<0.01. ***P<0.001.