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. 2020 Jun 24;8(1):e000958. doi: 10.1136/jitc-2020-000958

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Representative images for (A–D) immune checkpoint inhibitor-associated duodenitis (ICI-Duo), (E–H) ICI-celiac disease (CeD), (I–L) CeD, and (M–P) normal duodenum are shown for routine H&E and immunostains for CD3, CD8, and T-cell receptor (TCR) γδ, respectively. In comparison to normal duodenum, ICI-Duo, ICI-CeD, and CeD show marked villous blunting, with a variably increased intraepithelial CD3+ CD8+ T cells. However, CeD is further characterized by a marked increase in intraepithelial γδ T cells compared with the other groups.