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. 2020 Jun 24;7(1):e000388. doi: 10.1136/bmjgast-2020-000388

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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LGR5+ cells were identified by in situ hybridisation in (A) humans and (B) rats. LGR5+ cells are apparent in the base of the crypts between Paneth cells. LGR5 cells in humans remained elevated until the age of 15 before declining to adult values (continuous linear regression, p<0.001). For rats, LGR5+ cells declined earlier in ontogeny after day 14 of life (categorical linear regression, p<0.01). LGR5, leucine-rich repeat-containing G-protein coupled receptors.