Table 1.

Effect of 5 days of recombinant Dickkopf (100 ng subcutaneously) treatment on the small intestine of 16-day-old rats

Group	Crypt fission	Mitotic count/crypt section	LGR5 count/crypt section
Control	11 (2.0)*	2.0 (0.4)†	2.8 (0.4)*
Dickkopf-treated	3 (0.6)*	2.0 (0.4)†	1.2 (0.2)*

Data are given as mean (SD) of five animals in each group.

*P<0.0001.

†Not significant.

LGR5, leucine-rich repeat-containing G-protein coupled receptors.