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. 2020 Jun 24;8(1):e000792. doi: 10.1136/jitc-2020-000792

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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HDRBT significantly increased the density of CD4⁺FOXP3⁺ T cells and antigen presenting cells. Multiplex IHC was performed on PCa biopsies pre-HDRBT and post-HDRBT (n=24 patients). (A) Cumulative barplots of mean immune cell density either pre-HDRBT or post-HDRBT. P values calculated from two-tailed student’s t-test with * indicating p<0.05. (B) Immune subset density calculated from total number of identified immune phenotypes (see table 2) per square millimeter pre-HDRBT or post-HDRBT in each of the two designated tissue zones: (i) nontumor or (ii) tumor-containing. Statistical significance was calculated using a nonparametric Wilcoxon signed-rank test. P values indicated were appropriate. *P<0.05, **p<0.01, ***p<0.001. HDRBT, high dose-rate brachytherapy; IHC, immunohistochemistry; PCa, prostate cancer.