Table 3.

Top 20 significantly perturbed median spatial relationships in PCa tissue in response to HDRBT

Target	Neighbor	ANOVA p value
CD8+T cells	CD8+T cells	0.00097
T cells	DC	0.0048
MΦ	DC	0.0072
DNT cells	Tregs	0.018
B cells	DC PDL1+	0.04
CD4+T cells	CD8+T cells	0.04
HMWCK-PDL1+	CD8+T cells	0.046
T cells	MΦ	0.056
DNT cells	CD8+T cells	0.06
T cells	DC PDL1+	0.081
HMWCK-PDL1+	Tregs	0.095
CD8+T cells	HMWCK-PDL1+	0.1
MΦ	DC PDL1+	0.11
HMWCK+PDL1-	CD8+T cells	0.11
CD4+T cells	CD4+T cells	0.14
Tregs	CD8+T cells	0.16
HMWCK-PDL1+	CD4+T cells	0.16
B cells	DC	0.17
CD4+T cells	HMWCK-PDL1+	0.18
DNT cells	HMWCK-PDL1+	0.22

HDRBT, high dose-rate brachytherapy; PCa, prostate cancer.