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. 2020 Jun 24;8(1):e000182. doi: 10.1136/jitc-2019-000182

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Effect of macrophage and CSF-1R inhibition on the specific CD8 T cell clone cytotoxic activity against MPM cells. Meso 34 NanoLuc cells were cultured with or without monocytes (Mono) in low adherence conditions. After 3 days, a MUC1-specific CD8 T cell clone was added for 24 hours. Then, supernatants were collected and NanoLuc activity was measured to determine cell lysis. (A) Effect of the presence of macrophages on the cytotoxic activity of the MUC1-specific T cell clone. Results are means±SEM of four independent experiments. Meso34 vs Meso34+Mono: *p<0.05. (B) Impact of the inhibition of CSF-1R, using GW2580 (1 µM), on the T cell clone cytotoxic activity. **p<0.01; ***p<0.001. CSF-1R, colony stimulatingfactor-1 Receptor; MPM, malignant pleural mesothelioma; RLU, relative light units.