Table 3.
Initial Assessment | Final Assessment | |||
---|---|---|---|---|
Screening Performance Metric | Estimate | 95% CI | Estimate | 95% CI |
Standard performance measures | ||||
Cancer detection rate, per 1000 | 4.1 | 3.9, 4.3 | 4.1 | 3.8, 4.3 |
Interval cancer rate, per 1000 | 0.69 | 0.64, 0.74 | 0.77 | 0.71, 0.83 |
Sensitivity, % | 85.7 | 84.8, 86.6 | 84.1 | 83.0, 85.1 |
Specificity, % | 91.8 | 91.0, 92.4 | 97.4 | 97.0, 97.6 |
Screening benefit | ||||
Stage I or IIa screen-detected invasive cancers, per 1000 | 2.7 | 2.5, 2.8 | 2.6 | 2.5, 2.8 |
Screening false-alarms | ||||
False-positive recall for additional imaging, per 1000 | 82.1 | 75.3, 89.4 | NA | NA |
False-positive short interval follow-up recommendation, per 1000 | NA | NA | 16.5 | 13.9, 19.5 |
False-positive biopsy recommendation, per 1000 | NA | NA | 9.8 | 8.5, 11.3 |
Screening failures | ||||
Stage IIb or higher interval invasive cancers, per 1000 | 0.16 | 0.15, 0.18 | 0.18 | 0.16, 0.20 |
Stage IIb or higher screen-detected invasive cancers, per 1000 | 0.29 | 0.26, 0.33 | 0.27 | 0.24, 0.31 |
CI, confidence interval; NA, not applicable.