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. 2020 Jun 26;11:3236. doi: 10.1038/s41467-020-17052-4

Fig. 6. Nauclefine inhibits growth of human tumor xenografts in mice.

Fig. 6

a Nauclefine (200 nM) was used to treat HeLa-luc, HeLa-KO PDE3A-luc, or HeLa-KO SLFN12-luc cells for 48 h, then cells were stained by methylene blue. b Mice implanted with WT HeLa cells were intratumorally injected with vehicle (n = 4) or nauclefine (n = 5) for 22 days. Tumor volumes were measured on the indicated days. Student’s t test (two-tailed, unpaired) was performed with mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ns not significant. c Mice (n = 4) implanted with WT or mutant HeLa cells were intratumorally injected with vehicle or nauclefine. The luciferase substrate was intraperitoneally injected to visualize tumor size.