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. 2020 Jun 26;10:10425. doi: 10.1038/s41598-020-66829-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum concentration-time profile and tissue concentration of antisense and sense strands of HPRT.siRNA following a single SC bolus in C57BL/6 mice (a) 0–96 h in serum (n = 2 animals per time point). Serum concentration-time profile of x.siRNA (b) and y.siRNA (d) 0–48 h on day 1 and day 8 following a 10 mg/kg SC Bolus in male Sprague Dawley rats. Corresponding tissue concentrations of x.siRNA (c) and y.siRNA (e) 24 h post-dose following a QWx3 dosing regimen. Rat data plotted as individual replicates (n = 5 animals per time point). Mean data is shown with error bars representing standard deviation.