Table 2.

Regulators that may mediate age-related changes in gene expression.

Upstream Regulator	Activation Z-score	p-value
OSM	2.2	0.0001
Butyric acid	2.0	0.0099
CSF3	2.0	0.0140
THRB	2.0	0.0009
PP1	2.0	0.0001
Mir-16-5p	2.0	0.0234
PRDM1	1.6	0.0012
PS98059	1.6	0.0099
NFKBI	1.6	0.0094
IL6	1.5	0.0138
MYD88	−1.6	0.0027
TP53	−1.7	0.0393
ERK1/2	−1.8	0.0047
PPARA	−1.9	0.0021
β-estradiol	−2.0	0.0002
AKT1	−2.0	0.0003
MYB	−2.0	0.0038
FGF2	−2.2	0.0434
PI3K complex	−2.2	0.0009