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. 2020 Jun 26;6:27. doi: 10.1038/s41523-020-0169-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Percentage of tumor stromal cells staining positive for immunohistochemistry markers Ki-67 (a), p53 (b), and β-catenin (c) in fibroadenoma (FA), low-grade phyllodes tumor (LGP), and high-grade phyllodes tumor (HGP) is plotted. Center line represents median percentage of tumor stromal cells staining positive for each marker; the lower bound of box represents first quartile; the upper bound of box represents third quartile; and whiskers extends to the lowest and highest staining percentage of each marker. Note there is overlap in immunohistochemistry staining in the three entities. Wilcoxon-Mann–Whitney tests show statistically significant difference (p < 0.05) in Ki-67 and p53 staining from FA to LGP to HGP. There is no difference in β-catenin staining between FA and LGP, but there is statistically significant difference in nuclear staining for HGP compared with FA and LGP.