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. 2020 Jun 26;10:10426. doi: 10.1038/s41598-020-67133-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Morris water maze probe trial search. For each of the four groups, the percent of time (of the 60-second probe trial) that was spent in each of the four virtual counters are shown as function of quadrant relative to the location of the target quadrant (Target, Adjacent-clockwise, Opposite, Adjacent-counterclockwise). Note the significant reduction in target search bias in the trisomic mice, and the reduction in target search bias in the groups given EGCG. *Significantly greater than other three quadrants for the same group; ^#Significantly greater than the time in Target of all other groups.