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. 2020 Jun 26;10:10426. doi: 10.1038/s41598-020-67133-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Western blot analyses of relative DYRK1A protein levels for cerebral cortex, hippocampus, and cerebellum in 68-day-old euploid and trisomic male mice. DYRK1A from each brain region was normalized to actin as a loading control, then each sample ratio was expressed as a relative proportion of the mean value of the euploid-PBS control group for that brain region. DYRK1A was significantly overexpressed in trisomic mice only in the cerebral cortex (main effect of genotype, p = 0.034).