Table 3.
Free testosterone levels in relation to genotypes in the PCOS group. Data are presented as the geometric means (95% CI). 9.56 × 10−1.
Nearest gene | SNP | Genotype | n | Free testosterone (ng/dL) |
P |
---|---|---|---|---|---|
FSHB | rs11031006 | GG | 762 | 0.75 (−0.33, −0.26) | 1.94 × 10−3 |
AA + AG | 100 | 0.84 (−0.23, −0.04) | |||
FSHR | rs2268361 | AA | 205 | 0.72 (−0.29, −0.22) | 0.060 |
GG + GA | 657 | 0.77 (−0.29, −0.22) | |||
LHCGR | rs10176989 | AA | 602 | 0.78 (−0.40, −0.28) | 6.90 × 10−3 |
CC + CA | 260 | 0.71 (−0.028, −0.21) | |||
TOX3 | rs11075466 | AA | 337 | 0.75 (−0.34, −0.24) | 0.50 |
GG + GA | 525 | 0.77 (−0.31, −0.23) | |||
RAB5B | rs705704 | GG | 471 | 0.77 (−0.30, −0.22) | 0.35 |
AA + GA | 391 | 0.74 (−0.34, −0.25) | |||
KHDRBS3 | rs10505648 | AA | 767 | 0.75 (−0.31, −0.24) | 0.62 |
GG + GA | 95 | 0.80 (−0.35, −0.16) | |||
YAP1 | rs1894116 | AA | 551 | 0.77 (−0.30, −0.22) | 0.19 |
GG + GA | 311 | 0.74 (−0.36, −0.25) | |||
THADA | rs13429458 | CC | 335 | 0.78 (−0.43, −0.14) | 0.12 |
AA + AC | 518 | 0.74 (−0.31, −0.24) | |||
DENDD1A | rs2479106 | AA | 463 | 0.72 (−0.35, −0.27) | 0.020 |
GG + GA | 399 | 0.80 (−0.28, −0.19) | |||
INSR | rs2059807 | AA | 426 | 0.75 (−0.31, −0.22) | 0.51 |
GG + GA | 436 | 0.77 (−0.33, −0.24) | |||
C9orf3 | rs4385527 | GG | 554 | 0.76 (−0.31, −0.23) | 0.62 |
AA + AG | 305 | 0.77 (−0.34, −0.23) | |||
SUMO1P1 | rs6013809 | CC | 334 | 0.75 (−0.34, −0.24) | 0.47 |
AA + AC | 520 | 0.76 (−0.31, −0.23) |
All results were adjusted for age and body mass index.
CI, confidence interval; PCOS, polycystic ovary syndrome; SNP, single nucleotide polymorphism.