Table 1.
Common and unique characteristics of inflammatory DSC compared to Wallerian DSC
| Characteristics of DSC | Wallerian DSC | Inflammatory DSC | |
|---|---|---|---|
| Cytoplasmic hypertrophy | + | + | Evidence of DSC |
| Induction of c-jun/p75 | + | + | Dedifferentiation markers |
| Autolysosome | + | + | An executor of myelin clearance |
| Myelinosome | + | + | Evidence of DSC |
| Loss of apposition | + | + | Related to cytoplasmic hypertrophy |
| Junctional protein destruction | + | + | General response of DSC |
| Paranodal retraction | + | + | General response of DSC |
| Myelin exocytosis (exposure to basal lamina) | + | + | Evidence of DSC |
| Myelin Fragmentation, Ovoid formation | + | − | Secondary to axonal degeneration |
| Ovoid incorporation of SLI | + | − | Secondary to axonal degeneration |
| Axon degeneration | + | − | Secondary to axonal injury |
| Myelin uncompaction | − | + | Related to myelin lamella degeneration |
| Intraperiod line separation | − | + | Related to myelin lamella degeneration |
| Outer mesaxon separation | − | + | Related to junctional region destruction |
DSC demyelinating Schwann cell, SLI Schmidt-Lanterman Incisures