Table 3.

Hydrophobic compounds found in NMR analysis of hippocampus extracts

Chemical shift (ppm)	Compound/functional group	VPA			THAL
		% of control	ANOVA	VIP value	% of control	ANOVA	VIP value
6.87	Unassigned 1	85	F(1,21) = 2.920	1.06	86	F(1,23) = 1.665
			p = 0.103			p = 0.210
6.09	(–HC(2,4)=) Estriol	78	F(1,21) = 5.222	1.35	71	F(1,23) = 9.735	1.37
			p = 0.033*			p = 0.005*
5.87	(–C(4)H=C(5)H–) Testosterone	165	H(1) = 0.683	2.27	53	H(1) = 1.137	1.52
			p = 0.407			p = 0.286
5.14	(–HC=CH–) Olefinic group in MUFA	93	F(1,21) = 0.228		96	H(1) = 4.720	1.35
			p = 0.638			p = 0.030*
5.03	Unassigned 2	82	F(1,21) = 0.690	1.67	117	F(1,23) = 0.582	1.16
			p = 0.416			p = 0.454
4.70	Unassigned 3	68	H(1) = 2.804	1.54	112	H(1) = 0.0680
						p = 0.794
			p = 0.094
4.15	(–C(2)H–) Sphingomyelin (d18:1/16:0)	103	F(1,21) = 0.0719		119	F(1,23) = 2.359
						p = 0.139
			p = 0.791
3.88	(–CH2–CH2–N(–CH3)3) L-α-Phosphatidylcholine (16:0/18:2)	104	F(1,21) = 0.145		124	H(1) = 3.123
			p = 0.708			p = 0.077
3.68	(ROCH2–CHOH–CH2OH) in glyceryl group in 1-MG	112	F(1,21) = 0.556		145	F(1,23) = 7.328	1.10
			p = 0.465			p = 0.013*
3.24	(–O–CH2–CH2–NH3) L-α-Phosphatidylethanolamine (18:0/18:0)	91	F(1,21) = 0.515		101	F(1,23) = 0.00762
			p = 0.483
						p = 0.932
2.30	(–OCO–CH2–), (–COOH–CH2–) Acyl groups in 1,3-DG, 1-MG, and FA	107	F(1,21) = 0.262		93	F(1,23) = 0.225
			p = 0.614			p = 0.643
2.22	(–C(α)H2–) in saturated FA, MUFA, and PUFA	64	F(1,21) = 11.580	1.60	61	F(1,23) = 10.494	1.37
						p = 0.005*
			p = 0.003*
2.00	(–CH2–CH=CH–) in acyl groups of FA and phospholipids	88	F(1,21) = 1.093		103	F(1,23) = 0.0717
			p = 0.310			p = 0.792
1.70	(–C(15)H2–) Palmitic acid in L-α- lysophosphatidylcholine and FA	84	H(1) = 2.381	1.17	140	H(1) = 3.545	1.07
			p = 0.123			p = 0.060
1.60	(–OCO–CH2–CH2–) in acyl groups in 1,3-DG, 1-MG, and FA	89	F(1,21) = 1.516		106	F(1,23) = 0.359
			p = 0.233			p = 0.555
1.28	(−(CH2)n–) in acyl groups in FA	95	F(1,21) = 0.365		106	F(1,23) = 0.509
			p = 0.552			p = 0.483
1.08	(–C(21)H3) Cholestenol	101	F(1,21) = 0.0148		124	p = 0.029*
			p = 0.904
0.98	(–C(ω)H3) in PUFA/MUFA	108	F(1,21) = 0.385		131	F(1,23) = 6.927	1.21
			p = 0.542			p = 0.015*
0.93	(–C(21)H3) Free cholesterol and 25-hydroxycholesterol	104	F(1,21) = 0.118		125	F(1,23) = 6.076	1.10
			p = 0.734			p = 0.022*
0.88	(–CH3) in acyl groups of FA and sterols	93	F(1,21) = 1.000		107	F(1,23) = 0.805
			p = 0.329			p = 0.379
0.72	(–C(18)H3) 24-Hydroxycholesterol	70	H(1) = 7.788	1.34	83	F(1,23) = 2.228
			p = 0.005*			p = 0.150
0.69	(–C(18)H3) Free cholesterol and cholesterol esters	103	F(1,21) = 0.0971		121	F(1,23) = 5.099	1.00
						p = 0.034*
			p = 0.759
0.62	(–C(18)H3) Progesterone	87	F(1,21) = 0.233	1.03	113	F(1,23) = 0.240	1.28
			p = 0.635			p = 0.629
0.53	(–C(18)H3) Lathosterol	108	F(1,21) = 0.950		115	F(1,23) = 2.759
			p = 0.341			p = 0.111

Only VIP values > 1 obtained in MVA analysis are presented

^*Statistically significant