Table 1.
Characteristics of the RE-DUAL PCI population: proton pump inhibitor (PPI) vs no PPI at baseline
| PPI at baseline, yes | PPI at baseline, no | |
|---|---|---|
| Total (n = 1641) | Total (n = 1037) | |
| Demographic data | ||
| Age, mean (SD), years | 71.0 (8.7) | 70.4 (8.6) |
| Male sex, n (%) | 1220 (74.3) | 813 (78.4) |
| CrCl, mL/min, mean (SD)a | 76.5 (29.5) | 80.5 (29.3) |
| Medical and surgical history | ||
| Prior MI, n (%) | 458 (27.9) | 229 (22.1) |
| Prior CAD, n (%) | 1096 (66.8) | 701 (67.6) |
| Prior PCI, n (%) | 585 (35.6) | 311 (30) |
| LV ejection fraction,b mean (SD), % | 50.6 (12.3) | 51.7 (12.8) |
| Heart failure, n (%) | 570 (34.7) | 350 (33.8) |
| Diabetes mellitus, n (%) | 615 (37.5) | 358 (34.5) |
| Hypertension, n (%) | 912 (55.6) | 479 (46.2) |
| Currently smoking,cn (%) | 214 (13.0) | 120 (11.6) |
| Previous GI bleeding, ulcerative GI disease, or gastritis, n (%) | 135 (8.2) | 44 (4.2) |
| Prior major bleeding or predisposition to bleeding, n (%) | 18 (1.1) | 13 (1.3) |
| CHA2DS2-VASc score, mean (SD) | 3.7 (1.6) | 3.5 (1.6) |
| Modified HAS-BLED score, mean (SD) | 2.7 (0.7) | 2.7 (0.7) |
| In-hospital approach | ||
| Indication for PCI: ACS, n (%) | 875 (53.3) | 478 (46.1) |
| Radial access,dn (%) | 1054 (64.2) | 649 (62.6) |
| Only one coronary stent,en (%) | 1326 (80.8) | 816 (78.7) |
| Use of DES only,fn (%) | 1367 (83.3) | 843 (81.3) |
| UFH use in index procedure, n (%) | 1396 (85.1) | 859 (82.8) |
| Baseline medications | ||
| Clopidogrel, n (%) | 1451 (88.4) | 880 (84.9) |
| Statins | 1455 (88.7) | 879 (84.8) |
| Oral hypoglycemic drugs | 430 (26.2) | 255 (24.6) |
| ACE inhibitors | 912 (55.6) | 497 (47.9) |
| Angiotensin receptor blockers | 535 (32.6) | 334 (32.2) |
| β-blockers | 1387 (84.5) | 844 (81.4) |
Note, 47 patients with missing information on PPI use at baseline are excluded
ACE angiotensin converting enzyme, ACS acute coronary syndrome, CAD coronary artery disease, CrCl creatinine clearance, DES drug-eluting stent, GI gastrointestinal, LV left ventricular, MI myocardial infarction, PCI percutaneous coronary intervention, SD standard deviation, UFH unfractionated heparin
aMissing in 221 patients
bMissing in 183 patients
cMissing in one patient
dMissing in 20 patients
eMissing in 50 patients
fMissing in seven patients