Fig. 4.

Kaplan–Meier overall survival curves in the paediatric HGG cohort. High expression of cytoplasmic TrxR (a) and Trx (c) is associated with adverse overall survival (P = 0.002 and P = 0.007, respectively). No significant associations are found between the expression of nuclear TrxR (b), nuclear Trx (d), or TxNIP (e) and overall survival (P = 0.084, 0.482 and 0.181, respectively). Curves show low (blue line) and high protein expression (green line) with significance determined using the log-rank test. The numbers below the Kaplan–Meier curves are the number of patients at risk at the specified month