Fig. 5.

Kaplan–Meier overall survival curves in the MB cohort. High expression of cytoplasmic TrxR (a), cytoplasmic Trx (c) and nuclear Trx (d) is associated with adverse overall survival (P = 0.013, P = 0.033 and P = 0.007, respectively). No significance is observed between nuclear TrxR (b) or TxNIP (e) expression and overall survival (P = 0.230 and P = 0.287, respectively). Curves show low (blue line) and high protein expression (green line) with significance determined using the log-rank test. The numbers below the Kaplan–Meier curve are the number of patients at risk at the specified month