Table 3.

Top ten of the most deregulated target genes of E2F1 described in the literature compiled in the ingenuity knowledge base

Gene symbol	Log2 FC uHSD v0.1/control	Log2 FC uHSD/control	Ingenuity knowledge base	Binding motif	Biological process
Aurkb	− 4.8	− 3.9	×	–	Cell cycle, cell division, mitosis
Ccna2	− 4.7	− 4.0	×	–	Cell cycle, cell division, mitosis
Ccnb2	− 4.4	− 3.6	×	×	Cell cycle, cell division, mitosis
Mcm10	− 4.2	− 3.2	×	–	DNA damage, DNA replication
Mybl2	− 4.2	− 3.5	×	–	Transcription, transcription regulation
Ect2	− 4.2	− 3.5	×	–	Cell cycle, cell division, differentiation, neurogenesis, protein transport, transport
Top2a	− 4.0	− 3.4	×	–	Chromatin organization
Rad54l	− 3.9	− 2.8	×	×	DNA damage, DNA repair
Birc5	− 3.8	− 2.5	×	–	Apoptosis, cell cycle, cell division, chromosome partition, mitosis, transcription, transcription regulation
Cdk1	− 3.6	− 3.0	×	–	Apoptosis, cell cycle cell division, mitosis

The Log2-fold change (FC) of the respective genes in both uHSD approaches compared to the low-seeded reference runs and the biological pathway of the translated proteins are listed