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. 2020 Jun 26;10:10435. doi: 10.1038/s41598-020-67349-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transverse stained (H&E) sections of the dorsal mice skin taken from different groups: (a) negative control, (b) irradiated control, GpA: animals were topically treated by Cur aqueous suspension, Gp B: animals were topically treated by Cur suspension, followed by irradiation after 1 h, Gp C: animals were topically treated by 100 mg of the selected Cur-loaded PEGylated lipid nanocarrier (PLN3), GpDi animals were topically treated by 100 mg of the selected Cur-loaded PEGylated lipid nanocarriers (PLN3), followed by irradiation after 1 h showing the acanthosis (increasing thickness of the epidermal layer, indicated by the arrow) and GpDii the subcutaneous tissues of the same group with focal inflammatory cells infiltration (indicated by the arrow).