Table 1.

Composition, HLB, particle size analysis (PS, PDI &Z) and in-vitro release of the Cur-loaded PEGylated lipid nanocarriers (PLN).

Formula	Surfactant	HLB value	E.E	PS (nm)	PDI	Z	Q after 24 h	Q after 48 h
PLN1	S85	1.8	35.51 ± 2.05	520.00 ± 25.23	1 ± 0.09	− 35.90	15.01 ± 3.01	20.45 ± 4.21
PLN2	S20	8.6	38.00 ± 3.04	260.01 ± 24.63	0.513 ± 0.03	− 31.71	5.52 ± 1.51	7.52 ± 2.65
PLN3	T80	15	40.01 ± 2.10	167.60 ± 15.12	0.323 ± 0.02	− 26.91	75.02 ± 4.61	98.25 ± 6.89
PLN4	T20	16.7	40.02 ± 2.11	182.00 ± 15.56	0.325 ± 0.03	− 17.92	40.10 ± 4.00	50.20 ± 4.62

All values present the mean ± SD (n = 3).

Hydrophilic lipophilic balance (HLB)/average particle size (PS)/polydispersity index (PDI)/zeta potential (Z)/encapsulation efficiency (EE)/cumulative amount of drug release % (Q) after 24 h or 48 h.

Span 85 (S85)/Span 20 (S20)/Tween 80 (T80)/Tween 20 (T20).