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. 2020 Jun 26;10:10468. doi: 10.1038/s41598-020-67527-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Change of PERG in a patient randomized to group A: (a) baseline PERG (current topical therapy alone); (b) PERG at month 4 (at the end of the period of current topical therapy + PEA 600 mg one tablet a day's assumption); and (c) PERG at month 8 (at the end of the period in which the patient returned to topical therapy alone). (This example is an extreme case where the changes in amplitude are very evident and impressive).