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. 2020 Jun 26;10(6):72. doi: 10.1038/s41408-020-0339-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Dose response curves of B-R-03 wild type (WT) and indicated gene knockout (KO) ALL are given. a Moxidectin (Mox; black), ivermectin (Ive; orange), and milbemycin (Mil; green) induce cell death in WT (continuous lines) and Caspases-3 and -7 KO (C3/C7KO; dotted lines) ALL. b Moxidectin induces cell death in WT (black), C3/C7KO (gray), Caspases-3/-7/-2 triple knockout (C3/C7/C2KO; green), and Caspases-3/-7/-6 triple knockout (C3/C7/C6KO; orange) ALL. c Moxidectin (black), ivermectin (orange), and milbemycin (green) induce cell death in WT (continuous lines) and RIPK1KO (dotted lines) ALL. d Moxidectin induces cell death in WT (black), C3/C7KO (gray), RIPK1KO (orange), and combination of C3/C7 and RIPK1 knockout (C3/C7+RIPK1KO; green). All the dose response curves were normalized to vehicle control, and performed in N = 3 independent experiments. Quantifications represent mean ± s.e.m.