Table 2.
Univariate and multivariate analyses of cancer special survival (CSS) and overall survival (OS) for 3,278 patients with colorectal SRCC.
| Variables | CSS | OS | ||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||
| P value | HR (95%CI) | P value | P value | HR (95%CI) | P value | |
| Year at diagnosis | 0.713 | NI | 0.865 | NI | ||
| 2004–2007 | ||||||
| 2008–2011 | ||||||
| 2012–2015 | ||||||
| Insured status | 0.599 | NI | 0.760 | NI | ||
| Uninsured/unknown | ||||||
| Any medicaid/insured | ||||||
| Age | 0.731 | NI | < 0.001 | < 0.001 | ||
| < 65 | Reference | |||||
| ≥ 65 | 1.712 (1.574,1.863) | |||||
| Marital status | 0.003 | 0.001 | < 0.001 | 0.001 | ||
| Unmarried | Reference | Reference | ||||
| Married | 0.863 (0.792,0.940) | 0.870 (0.802,0.943) | ||||
| Gender | 0.148 | NI | 0.440 | NI | ||
| Female | ||||||
| Male | ||||||
| Race | 0.232 | NI | 0.254 | NI | ||
| Black | ||||||
| White | ||||||
| Other | ||||||
| Primary site | < 0.001 | 0.001 | < 0.001 | < 0.001 | ||
| Cecum–transverse colon | Reference | Reference | ||||
| Descending colon–sigmoid | 1.137 (1.004.1.287) | 0.043 | 1.179 (1.048,1.327) | 0.006 | ||
| Multiple | 1.431 (1.034,1.980) | 0.031 | 1.327 (0.967,1.821) | 0.080 | ||
| Rectum | 1.182 (1.053,1.328) | 0.005 | 1.237 (1.107.1.383) | < 0.001 | ||
| Unknown | 1.397 (1.103,1.768) | 0.005 | 1.359 (1.081,1.708) | 0.009 | ||
| Grade | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| Grade I/II | Reference | Reference | ||||
| Grade III/IV | 1.679 (1.347,2.094) | < 0.001 | 1.672 (1.369,2.042) | < 0.001 | ||
| Unknown | 1.629 (1.282,2.069) | < 0.001 | 1.618 (1.300,2.013) | < 0.001 | ||
| Tumor size | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| ≤ 5 cm | Reference | Reference | ||||
| > 5 cm | 1.297 (1.170,1.438) | < 0.001 | 1.251 (1.137,1.375) | < 0.001 | ||
| Unknown | 1.276 (1.124,1.448) | < 0.001 | 1.299 (1.151,1.466) | < 0.001 | ||
| AJCC stage | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| I | Reference | Reference | ||||
| II | 1.210 (0.836,1.751) | 0.313 | 1.387 (1.033,1.864) | 0.030 | ||
| III | 3.353 (2.401,4.682) | < 0.001 | 2.917 (2.221,3.832) | < 0.001 | ||
| IV | 7.723 (5.539,10.769) | < 0.001 | 6.638 (5.051,8.725) | < 0.001 | ||
| Surgery | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||
| No surgery | Reference | Reference | ||||
| Local tumor excision/partial colectomy | 0.609 (0.506,0.734) | < 0.001 | 0.640 (0.536,0.764) | < 0.001 | ||
| Total colectomy | 0.693 (0.571,0.840) | < 0.001 | 0.744 (0.619,0.893) | 0.002 | ||
| Dissected lymph node | < 0.001 | 0.059 | < 0.001 | 0.011 | ||
| None or biopsy | Reference | Reference | ||||
| 1—3 | 0.798 (0.594,1.071) | 0.133 | 0.810 (0.615,1.068) | 0.136 | ||
| ≥ 4 | 0.813 (0.682,0.969) | 0.020 | 0.777 (0.659, 0.917) | 0.003 | ||
CSS: cancer‐specific survival; OS: overall survival; NI, not included in the multivariate survival analysis.