Figure 3.

Therapeutic efficacy of propranolol alone and in combination with chemotherapeutics in sarcoma cells expressing β-ARs. (A) SK-LMS-1 and SW-872 cells were incubated with propranolol (prop) ranging from 25 to 150 µM for 24–72 h. AS cells were incubated with 100 and 150 µM propranolol for 72 h. Histogram plots report the inhibition of cell viability as the mean value ± SD of three independent experiments (***p < 0.001; **p < 0.01; *p < 0.5 were calculated versus untreated cells). (B) Dose–response plots and CI showing the inhibition of cell viability and pharmacological interaction of drugs in SK-LMS-1, SW-872 and AS-O2 cells.