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Incidence of congenital heart defects in Nox2−/− mice at P0.
| Wild type (N = 35 of 5 litters) |
Nox2−/−
(N = 61 of 12 litters) |
|||
|---|---|---|---|---|
| N | % | N | % | |
| Normal | 35 | 100 | 40 | 65.6∗∗ |
| Abnormal | 0 | 0 | 21 | 34.4∗∗ |
| ASD | 0 | 0 | 11 | 18∗ |
| VSD | 0 | 0 | 11 | 18∗ |
| AVCD | 0 | 0 | 2 | 3.3 |
| BAV | 0 | 0 | 4 | 6.6 |
ASD: atrial septal defect; VSD: ventricular septal defect; AVCD: atrioventricular canal defect. ∗P < 0.05, ∗∗P < 0.01 vs. wild-type by the Chi-squared test.
