Table 3. Association of Garlic Supplementation With Gastric Cancer Incidence and Mortality Stratified by Alcohol Intake Among Participants With and Without Helicobacter pylori.
| Factor | Gastric cancer incidence | Gastric cancer mortality | ||||||
|---|---|---|---|---|---|---|---|---|
| No./total No.a | OR (95% CI)b | P value for interactionc | No./total No.a | HR (95% CI)d | P value for interactionc | |||
| Placebo | Active | Placebo | Active | |||||
| With H pylori | ||||||||
| Overall | 63/1092 (5.8) | 53/1080 (4.9) | 0.84 (0.57-1.23) | NA | 44/1092 (4.0) | 30/1080 (2.8) | 0.66 (0.42-1.06) | NA |
| Alcohol | ||||||||
| Ever | 38/501 (7.6) | 36/489 (7.4) | 0.99 (0.61-1.62) | .27 | 26/501 (5.2) | 24/489 (4.9) | 0.91 (0.52-1.60) | .04 |
| Never | 25/591 (4.2) | 17/591 (2.9) | 0.64 (0.34-1.22) | 18/591 (3.0) | 6/591 (1.o) | 0.31 (0.12-0.78) | ||
| No H pylori | ||||||||
| Overall | 18/539 (3.3) | 13/526 (2.5) | 0.73 (0.35-1.53) | NA | 10/539 (1.9) | 6/526 (1.1) | 0.60 (0.21-1.67) | NA |
| Alcohol | ||||||||
| Ever | 8/255 (3.1) | 8/243 (3.3) | 0.94 (0.33-2.70) | .31 | 5/255 (2.0) | 4/243 (1.6) | 0.73 (0.19-2.82) | .45 |
| Never | 10/284 (3.5) | 5/283 (1.8) | 0.45 (0.15-1.38) | 5/284 (1.8) | 2/283 (0.7) | 0.41 (0.07-2.38) | ||
Abbreviations: HR, hazard ratio; NA, not applicable; OR, odds ratio.
a
Number of participants with an event divided by total number of participants. Those with missing data on the examined independent factor or other covariates were excluded from the multivariable models.
b
Logistic regression adjusted for baseline histology, age, sex, history of ever using alcohol, and history of ever smoking.
c
P values for interactions were calculated by adding the interaction term between 2 items in the regression models in addition to the indicators of the 2 items being analyzed.
d
Cox regression adjusted for baseline histology, age, sex, history of ever using alcohol, and history of ever smoking.