Fig. 3.

Exosomal expression of circUHRF1 inhibits the function of NK cells. a Schematic diagram of the coculture model. b and c HCC cells inhibit NK cell secretion of IFN-γ and TNF-α. d HCC cells upregulate the expression of circUHRF1 in NK cells. e GW4869 inhibits HCC cell-induced circUHRF1 upregulation in NK cells. f and g The effect of GW4869 on HCC-induced IFN-γ and TNF-α secretion by NK cells. h CircUHRF1 silencing is accompanied by decreased exosomal circUHRF1. i and j Decreased exosomal circUHRF1 promotes HCC-induced IFN-γ and TNF-α secretion by NK cells. The data are presented as the mean ± SD; n = 3, *P < 0.05, **P < 0.01, NS: not significant