Table 3.
Univariate and multivariate analyses of factors associated with cumulative recurrence
| Cumulative Recurrence | ||||
|---|---|---|---|---|
| Multivariate | ||||
| Factors | Univariate, P | HR | 95% CI | P value |
| Sex (Female vs. Male) | 0.527 | NA | ||
| Age (years) (≤50 vs. > 50) | 0.393 | NA | ||
| HBsAg (Positive vs. Negative) | 0.266 | NA | ||
| HCVAb (Positive vs. Negative) | 0.494 | NA | ||
| Liver cirrhosis (Yes vs. No) | 0.802 | NA | ||
| Serum AFP, ng/mL (≤20 vs. > 20) | 0.472 | NA | ||
| Serum ALT, U/L (≤75 vs. > 75) | 0.615 | NA | ||
| Tumor size (diameter, cm) (> 5 vs ≤ 5) | 0.066 | NA | ||
| NK cell proportion in blood (≤ 8% vs. > 8%) | 0.149 | NA | ||
| TNM (III/IV vs I/II.) | 0.277 | NA | ||
| CircUHRF1 expression (High vs. Low) | 0.004 | 1.762 | 1.172–2.428 | 0.019 |
NA not adopted; AFP alpha-fetoprotein; HBsAg hepatitis B surface antigen; 95%CI 95% confidence interval; BCLC Barcelona-Clinic Liver Cancer, HR hazard ratio; Cox proportional hazards regression model