Figure 3.

Associations of aldosterone and renin with metabolic syndrome and metabolic derangements. A, Aldosterone was associated with the presence of metabolic syndrome, in line, patients with the metabolic syndrome had higher circulating aldosterone levels. Similar associations were observed for renin. Both aldosterone and renin associated with the number of positive NCEP criteria for metabolic syndrome. B, Aldosterone was associated with triglyceride levels, whereas renin associated with glucose levels. In line, renin associated with the HOMA-IR. C, Lipidomics was performed, and lipid particles clustered. D, Aldosterone was associated with the cluster of large to extra-large VLDL particles. E, Last, we observed a striking association of aldosterone with uric acid. HOMA-IR, Homeostatic Model Assessment for Insulin Resistance; NCEP, National Cholesterol Education Program, VLDL, very low-density lipoprotein.