Table 1.
Subgroup analysis in those without antihypertensives, comparing lowest to highest aldosterone tertiles
| Outcome parameter | Lowest tertile (mean [SD]) | Highest tertile (mean [SD]) | P |
|---|---|---|---|
| Peripheral blood cell composition | |||
| Leukocytes, 109/L | 5.38 (1.16) | 6.39 (1.72) | .001 |
| Neutrophils, 109/L | 3.06 (0.99) | 3.53 (1.27) | .032 |
| Lymphocytes, 109/L | 1.65 (0.06) | 2.11 (0.07) | < .001 |
| Monocytes, 109/L | 0.45 (0.12) | 0.52 (0.18) | .062 |
| Circulating markers | |||
| VEGF, pg/mL | 35.93 (20.41) | 62.34 (74.53) | .028 |
| Metabolic syndrome score | 1.96 (0.94) | 2.53 (1.17) | .002 |
| Metabolic markers | |||
| Urate, mmol/L | 0.35 (0.08) | 0.38 (0.09) | .040 |
| Triglycerides, mmol/L | 1.47 (0.58) | 1.74 (0.67) | .034 |
| XL VLDL, mmol/L | 0.069 (0.066) | 0.091 (0.071) | .028 |
| Metabolomics | |||
| Lineoleic acid | 6.97 (0.10) | 7.03 (0.12) | .010 |
| Arachidonic acid | 5.93 (0.11) | 6.01 (0.13) | .010 |
| Adrenic acid | 4.93 (0.14) | 5.03 (0.16) | .010 |
| Docosapentaenoic acid | 5.28 (0.15) | 5.38 (0.20) | .010 |
| Prostaglandin F2A | 4.36 (0.06) | 4.39 (0.07) | .015 |
| Leukotriene B4 | 4.43 (0.07) | 4.47 (0.07) | .015 |
| Liver fat | 0.073 (0.096) | 0.107 (0.128) | .13 |
| Indicators of atherosclerosis | |||
| Plaque presence, % | 44 | 49 | .57 |
| Plaque thickness, cm | 2.25 (1.04) | 2.11 (0.48) | .79 |
| cIMT, µm | 769.5 (133.5) | 788.2 (148.7) | .79 |
| PWV, m/s | 9.28 (1.90) | 8.95 (1.71) | .79 |
Abbreviations: cIMT, carotid intima-medial thickness; PWV, pulse wave velocity; XL VLDL, extra-large very low-density lipoprotein.