Table 2.
Subgroup analysis in those without antihypertensives, comparing lowest to highest renin tertiles
| Outcome parameter | Lowest tertile (mean [SD]) | Highest tertile (mean [SD]) | P |
|---|---|---|---|
| Peripheral blood cell composition | |||
| Leukocytes | 5.68 (1.40) | 6.31 (1.57) | .09 |
| Neutrophils | 3.12 (0.96) | 3.68 (1.17) | .01 |
| Lymphocytes | 1.85 (0.55) | 1.89 (0.57) | .93 |
| Monocytes | 0.48 (0.14) | 0.51 (0.15) | .27 |
| Platelets | 229.5 (51.1) | 238.8 (53.7) | .23 |
| Circulating markers | |||
| IL-6, pg/mLa | 2.13 (1.55-2.87) | 2.45 (1.70-3.42) | .17 |
| IL18BP, ng/mL | 16.77 (5.15) | 17.23 (4.14) | .12 |
| Adiponectin, µg/mL | 5.20 (2.41) | 4.67 (2.38) | .17 |
| Metabolic syndrome score | 2.02 (1.06) | 2.24 (1.19) | .12 |
| Metabolic markers | |||
| Urate | 0.36 (0.08) | 0.35 (0.09) | .37 |
| Triglycerides, mmol/L | 1.53 (0.62) | 1.61 (0.68) | .36 |
| Glucose, mmol/L | 5.25 (0.60) | 5.76 (1.75) | .03 |
| Fat distribution | |||
| Liver fat | 0.079 (0.113) | 0.093 (0.087) | .57 |
| VAT | 92.59 (25.43) | 110.25 (34.56) | .02 |
| Indicators of atherosclerosis | |||
| Plaque presence, % | 47 | 53 | .57 |
| Plaque thickness, cm | 2.32 (1.01) | 2.11 (0.48) | .47 |
| cIMT, µm | 794.8 (175.1) | 775.9 (125.9) | .47 |
| PWV, m/s | 9.43 (1.53) | 9.25 (1.92) | .47 |
Abbreviations: cIMT, carotid intima-medial thickness; IL-6, interleukin 6; IL18BP, interleukin-18-binding protein; VAT, visceral adipose tissue.
aMedian (25th-27th percentile).