Table 6.

Coexpression network comparison between high and low BMD subjects in “REACTOME_SIGNALING_BY_TGF_BETA.”

	Low_BMD group	High_BMD group
Average absolute cross correlation	0.25	0.28
Degree centrality of hub gene	FURTIN (7)	SMAD3 (6)
Degree centrality of TGFB1	5	2
Normalized betweenness centrality of hub gene	FURIN (0.26)	SMAD3 (0.29)
Normalized betweenness centrality of TGFB1	0.21	0.00
Normalized closeness centrality of hub gene	FURTIN (1.35)	SMAD (1.35)
Average normalized closeness centrality	1.0	1.1

FURTIN is a hub gene in the low BMD group and it connected to 7 genes in the coexpression structure; SMAD is a hub gene in the high BMD group and it has 6 neighbors. The connections of TGFB1 in 2 BMD groups are 5 and 2 respectively. The normalized shortest paths that pass through FURIN in the low BMD group is 0.26; the normalized shortest paths that pass through SMAD3 in low the BMD group is 0.29. The normalized shortest paths that pass through TGFB1 in 2 BMD groups are 0.21 and 0 respectively. The normalized mean distance from FURIN to other vertices (genes) is 1.35 in the low BMD group, and the normalized mean distance from SMAD3 to other vertices (genes) is 1.35 as well in the high BMD group.