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Ligands of TLR2 and TLR4
| Type of Ligands | TLR2/1/6 | TLR4 |
|---|---|---|
| Microbial ligands | Triacylated lipopeptides diacylated lipopeptides glycolipids zimozan lipoteichoic acid (LTA) peptidoglycan (PGN) |
Lipopolysaccharide (LPS) |
| Endogenous ligands | High-mobility group protein B1 (HMGPB1) heat shock proteins (HSPs) hyaluronan fibronectin | HMGPB1 fibrinogen heparin sulphate hyaluronic acid fibronectin |
| Synthetic ligands | Pam3CSK4 Pam2CGDPKHPKSF (FSL-1) |
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