Table 4.
Correlations of Proliferation (Ki67) and Angiogenesis (CD31) with Age, Gender and Advancement of the Disease
| Variables | Ki67 | CD31 | ||
|---|---|---|---|---|
| Ki67 Score (Median, Range) | Test of Significance | CD31 MVD (Median, Range) | Test of Significance | |
| Age/years | rs=0.536 p<0.001* |
rs=0.485 p<0.001* |
||
| ≤40y | 3(1.0–70) | z=4.57 p<0.001* |
22.5(9–80) | z=4.04 p<0.001* |
| >40y | 10(1.0–75) | 42.5(16–94) | ||
| Gender (n=59) | ||||
| Male | 7 (1–75) | z=2.25 p=0.02* |
28(9–94) | z=1.81 p=07 |
| Female | 4 (1–70) | 23.5(11–85) | ||
| Skin (n=59) | ||||
| T1 | 5(1–40)a | KW p=0.001* |
24.5(12–68)a | KW p<0.001* |
| T2 | 7(1–75)a | 30(14–94)ab | ||
| T3 | 35(20–70)b | 67.5(58–80)c | ||
| T4 | 65(60–70)b | 75(71–79)bc | ||
| Lymph node (n=59) | ||||
| N0 | 5 (1–60) | z=5.56 p<0.001* |
25(9.0–74) | z=5.34 p<0.001* |
| N1,2,3 | 52.5(20–75) | 68.5(58–94) | ||
| Blood (n=59) | ||||
| B0 | 7.5(1–75) | z=2.68 p=0.007* |
32.5(12–94) | z=2.34 p=0.019* |
| B1,2 | 70 (55–70) | 79(63–80) | ||
| Metastasis (n=59) | ||||
| M0 | 8 (1–75) | Z=1.62 p=0.11 |
36 (12–94) | Z=1.59 p=0.11 |
| M1 | 70 (70–70) | 80(80–80) | ||
| Stage* (n=49) | ||||
| Early stage (stage I) | 5(1–30)A | KW p<0.001* |
25(12–60)A | KW p=0.001* |
| Late stages | ||||
| II | 30(5–50)B | 64(22–74)BC | ||
| III | 65(60–70)C | 75(71–79)BD | ||
| IV | 40(40–40)ABC | 67(67–67)ACD | ||
Notes: abc, ABCD Similar superscripted letters denote non-significant difference within same column, Z; Mann–Whitney U-test, *p value is statistically significant if ≤0.05.
Abbreviation: KW; Kruskal–Wallis test.