Table 1.
Distribution of Enterobacterales, CR-Enterobacterales and CS-Enterobacterales from 2015 to 2017 in IAIs, UTIs and RTIs (N, %)
| 2015 | 2016 | 2017 | Total | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IAI | UTI | RTI | Subtotal | IAI | UTI | RTI | Subtotal | IAI | UTI | RTI | Subtotal | ||
| Enterobacterales | 1216 | 742 | 245 | 2203 | 1136 | 741 | 498 | 2375 | 899 | 1000 | 636 | 2535 | 7113 |
| CR-Enterobacterales | 148 (12.2) | 59 (8.0) | 52 (21.2) | 259 (11.8) | 159 (14.0) | 76 (10.3) | 136 (27.3) | 371 (15.6) | 155 (17.2) | 113 (11.3) | 172 (27.0) | 440 (17.4) | 1070 (15.0) |
| CS-Enterobacterales | 970 (79.8) | 613 (82.6) | 176 (71.8) | 1759 (79.8) | 899 (79.1) | 608 (82.1) | 325 (65.3) | 1832 (77.1) | 679 (75.5) | 830 (83.0) | 424 (66.7) | 1933 (76.3) | 5524 (77.7) |
| CI-Enterobacterales | 98 (8.1) | 70 (9.4) | 17 (6.9) | 185 (8.4) | 78 (6.9) | 57 (7.7) | 37 (7.4) | 172 (7.2) | 65 (7.2) | 57 (5.7) | 40 (6.3) | 162 (6.4) | 519 (7.3) |
| Escherichia coli | 648 | 531 | 38 | 1217 | 618 | 519 | 72 | 1209 | 456 | 692 | 83 | 1231 | 3657 |
| CR-Escherichia coli | 47 (7.3) | 18 (3.4) | 5 (13.2) | 70 (5.8) | 52 (8.4) | 35 (6.7) | 10 (13.9) | 97 (8.0) | 39 (8.6) | 36 (5.2) | 12 (14.5) | 87 (7.1) | 254 (6.9) |
| CS-Escherichia coli | 573 (88.4) | 486 (91.5) | 33 (86.8) | 1092 (89.7) | 543 (87.9) | 463 (89.2) | 61 (84.7) | 1067 (88.3) | 408 (89.5) | 637 (92.1) | 69 (83.1) | 1114 (90.5) | 3273 (89.5) |
| CI-Escherichia coli | 28 (4.3) | 27 (5.1) | 0 (0.0) | 55 (4.5) | 23 (3.7) | 21 (4.0) | 1 (1.4) | 45 (3.7) | 9 (2.0) | 19 (2.7) | 2 (2.4) | 30 (2.4) | 130 (3.6) |
| Klebsiella pneumoniae | 331 | 114 | 150 | 595 | 330 | 137 | 289 | 756 | 223 | 179 | 397 | 799 | 2150 |
| CR-Klebsiella pneumoniae | 55 (16.6) | 22 (19.3) | 36 (24.0) | 113 (19.0) | 69 (20.9) | 28 (20.4) | 87 (30.1) | 184 (24.3) | 69 (30.9) | 45 (25.1) | 123 (31.0) | 237 (29.7) | 534 (24.8) |
| CS-Klebsiella pneumoniae | 264 (79.8) | 81 (71.1) | 112 (74.7) | 457 (76.8) | 249 (75.5) | 97 (70.8) | 187 (64.7) | 533 (70.5) | 144 (64.6) | 129 (72.1) | 266 (67.0) | 539 (67.5) | 1529 (71.1) |
| CI-Klebsiella pneumoniae | 12 (3.6) | 11 (9.6) | 2 (1.3) | 25 (4.2) | 12 (3.6) | 12 (8.8) | 15 (5.2) | 39 (5.2) | 10 (4.5) | 5 (2.8) | 8 (2.0) | 23 (2.9) | 87 (4.0) |
| Enterobacter cloacae | 100 | 16 | 19 | 135 | 60 | 22 | 39 | 121 | 83 | 31 | 37 | 151 | 407 |
| CR-Enterobacter cloacae | 15 (15.0) | 5 (31.3) | 3 (15.8) | 23 (17.0) | 11 (18.3) | 3 (13.6) | 9 (23.1) | 23 (19.0) | 11 (13.3) | 9 (29.0) | 6 (16.2) | 26 (17.2) | 72 (17.7) |
| CS-Enterobacter cloacae | 62 (62.0) | 8 (50.0) | 13 (68.4) | 83 (61.5) | 39 (65.0) | 12 (54.5) | 26 (66.7) | 77 (63.6) | 61 (73.5) | 20 (64.5) | 27 (73.0) | 108 (71.5) | 268 (65.8) |
| CI-Enterobacter cloacae | 23 (23.0) | 3 (18.8) | 3 (15.8) | 29 (21.5) | 10 (16.7) | 7 (31.8) | 4 (10.3) | 21 (17.4) | 11 (13.3) | 2 (6.5) | 4 (10.8) | 17 (11.3) | 67 (16.5) |
| Proteus mirabilis | 29 | 26 | 7 | 62 | 20 | 18 | 11 | 49 | 24 | 38 | 13 | 75 | 186 |
| CR-Proteus mirabilis | 9 (31.0) | 5 (19.2) | 1 (14.3) | 15 (24.2) | 2 (10.0) | 4 (22.2) | 3 (27.3) | 9 (18.4) | 7 (29.2) | 9 (23.7) | 2 (15.4) | 18 (24.0) | 42 (22.6) |
| CS-Proteus mirabilis | 8 (27.6) | 5 (19.2) | 0 (0.0) | 13 (21.0) | 8 (40.0) | 6 (33.3) | 6 (54.5) | 20 (40.8) | 2 (8.3) | 9 (23.7) | 2 (15.4) | 13 (17.3) | 46 (24.7) |
| CI-Proteus mirabilis | 12 (41.4) | 16 (61.5) | 6 (85.7) | 34 (54.8) | 10 (50.0) | 8 (44.4) | 2 (18.2) | 20 (40.8) | 15 (62.5) | 20 (52.6) | 9 (69.2) | 44 (58.7) | 98 (52.7) |
| Klebsiella aerogenes | 27 | 9 | 2 | 38 | 23 | 9 | 17 | 49 | 30 | 12 | 17 | 59 | 146 |
| CR-Klebsiella aerogenes | 4 (14.8) | 0 (0.0) | 1 (50.0) | 5 (13.2) | 5 (21.7) | 1 (11.1) | 1 (5.9) | 7 (14.3) | 2 (6.7) | 1 (8.3) | 1 (5.9) | 4 (6.8) | 16 (11.0) |
| CS-Klebsiella aerogenes | 13 (48.1) | 7 (77.8) | 1 (50.0) | 21 (55.3) | 8 (34.8) | 4 (44.4) | 10 (58.8) | 22 (44.9) | 22 (73.3) | 7 (58.3) | 14 (82.4) | 43 (72.9) | 86 (58.9) |
| CI-Klebsiella aerogenes | 10 (37.0) | 2 (22.2) | 0 (0.0) | 12 (31.6) | 10 (43.5) | 4 (44.4) | 6 (35.3) | 20 (40.8) | 6 (20.0) | 4 (33.3) | 2 (11.8) | 12 (20.3) | 44 (30.1) |
| Serratia marcescens | 9 | 4 | 10 | 23 | 10 | 15 | 35 | 60 | 15 | 5 | 37 | 57 | 140 |
| CR-Serratia marcescens | 2 (22.2) | 1 (25.0) | 0 (0.0) | 3 (13.0) | 3 (30.0) | 1 (6.7) | 12 (34.3) | 16 (26.7) | 9 (60.0) | 0 (0.0) | 11 (29.7) | 20 (35.1) | 39 (27.9) |
| CS-Serratia marcescens | 5 (55.6) | 1 (25.0) | 6 (60.0) | 12 (52.2) | 6 (60.0) | 11 (73.3) | 16 (45.7) | 33 (55.0) | 2 (13.3) | 2 (40.0) | 16 (43.2) | 20 (35.1) | 65 (46.4) |
| CI-Serratia marcescens | 2 (22.2) | 2 (50.0) | 4 (40.0) | 8 (34.8) | 1 (10.0) | 3 (20.0) | 7 (20.0) | 11 (18.3) | 4 (26.7) | 3 (60.0) | 10 (27.0) | 17 (29.8) | 36 (25.7) |
| Klebsiella oxytoca | 17 | 5 | 3 | 25 | 21 | 7 | 22 | 50 | 16 | 5 | 27 | 48 | 123 |
| CR-Klebsiella oxytoca | 1 (5.9) | 1 (20.0) | 1 (33.3) | 3 (12.0) | 3 (14.3) | 0 (0.0) | 7 (31.8) | 10 (20.0) | 3 (18.8) | 1 (20.0) | 7 (25.9) | 11 (22.9) | 24 (19.5) |
| CS-Klebsiella oxytoca | 15 (88.2) | 4 (80.0) | 2 (66.7) | 21 (84.0) | 16 (76.2) | 7 (100.0) | 13 (59.1) | 36 (72.0) | 13 (81.3) | 4 (80.0) | 18 (66.7) | 35 (72.9) | 92 (74.8) |
| CI-Klebsiella oxytoca | 1 (5.9) | 0 (0.0) | 0 (0.0) | 1 (4.0) | 2 (9.5) | 0 (0.0) | 2 (9.1) | 4 (8.0) | 0 (0.0) | 0 (0.0) | 2 (7.4) | 2 (4.2) | 7 (5.7) |
| Citrobacter freundii | 19 | 18 | 5 | 42 | 17 | 5 | 2 | 24 | 15 | 12 | 3 | 30 | 96 |
| CR-Citrobacter freundii | 1 (5.3) | 1 (5.6) | 0 (0.0) | 2 (4.8) | 2 (11.8) | 0 (0.0) | 1 (50.0) | 3 (12.5) | 3 (20.0) | 3 (25.0) | 1 (33.3) | 7 (23.3) | 12 (12.5) |
| CS-Citrobacter freundii | 15 (78.9) | 13 (72.2) | 5 (100.0) | 33 (78.6) | 12 (70.6) | 5 (100.0) | 1 (50.0) | 18 (75.0) | 11 (73.3) | 9 (75.0) | 1 (33.3) | 21 (70.0) | 72 (75.0) |
| CI-Citrobacter freundii | 3 (15.8) | 4 (22.2) | 0 (0.0) | 7 (16.7) | 3 (17.6) | 0 (0.0) | 0 (0.0) | 3 (12.5) | 1 (6.7) | 0 (0.0) | 1 (33.3) | 2 (6.7) | 12 (12.5) |
| Others | 36 (3.0%) | 19 (2.6%) | 12 (4.9%) | 66 (3.0%) | 37 (3.3%) | 9 (1.2%) | 11 (2.2%) | 57 (2.4%) | 37 (4.1%) | 26 (2.6%) | 22 (3.5%) | 85 (3.4%) | 208 (2.9%) |
Note: Other refers to isolates <1% of the total.
Abbreviations: IAI, intra-abdominal infection, UTI, urinary tract infection RTI respiratory tract infection; CS, carbapenem sensitive; CR, carbapenem-resistant; CI, carbapenem-intermediate.