Table 1.
IncobotulinumtoxinA doses administered, treatment patterns and injected muscles in the MP and OLEX
| Units (high dose, 400 U) | Units (low dose, 250 U) | mLa | Number of injection sitesa | |
|---|---|---|---|---|
| MP: Upper-limb treatment, with treatment of thumb-in-palm | ||||
| Flexed wrist | 100 | 62.50 | 2.0 | – |
| Flexor carpi radialisb | 50 | 31.25 | 1.0 | 1–2 |
| Flexor carpi ulnarisb | 50 | 31.25 | 1.0 | 1–2 |
| Clenched fist | 100 | 62.50 | 2.0 | – |
| Flexor digitorum superficialisb | 50 | 31.25 | 1.0 | 1–2 |
| Flexor digitorum profundusb | 50 | 31.25 | 1.0 | 1–2 |
| Flexed elbow and pronated forearm | 150 | 93.75 | 3.0 | – |
| Bicepsb | 100 | 62.50 | 2.0 | 2–4 |
| Pronator teresb | 50 | 31.25 | 1.0 | 1–2 |
| Thumb-in-palm | 50 | 31.25 | 1.0 | – |
| Flexor pollicis longusb | 20 | 12.50 | 0.4 | 1 |
| Adductor pollicisb | 20 | 12.50 | 0.4 | 1 |
| Flexor pollicis brevis or opponens pollicisb | 10 | 6.25 | 0.2 | 1 |
| MP: Upper-limb treatment, without treatment of thumb-in-palm | ||||
| Flexed wrist | 100 | 62.50 | 2.0 | – |
| Flexor carpi radialisb | 50 | 31.25 | 1.0 | 1–2 |
| Flexor carpi ulnarisb | 50 | 31.25 | 1.0 | 1–2 |
| Clenched fist | 100 | 62.50 | 2.0 | – |
| Flexor digitorum superficialisb | 50 | 31.25 | 1.0 | 1–2 |
| Flexor digitorum profundusb | 50 | 31.25 | 1.0 | 1–2 |
| Flexed elbow and pronated forearm | 200 | 125.00 | 4.0 | – |
| Bicepsb | 100 | 62.50 | 2.0 | 2–4 |
| Brachialisb | 50 | 31.25 | 1.0 | 1–2 |
| Pronator teresb | 50 | 31.25 | 1.0 | 1–2 |
| OLEX: Upper-limb treatment | Unitsc | mLc | Number of injection sitesa |
|---|---|---|---|
| Flexed wrist | – | ||
| Flexor carpi radialisd | 25–100 | 0.5–2.0 | 1–2 |
| Flexor carpi ulnarisd | 20–100 | 0.4–2.0 | 1–2 |
| Clenched fist | – | – | – |
| Flexor digitorum superficialisd | 25–100 | 0.5–2.0 | 1–2 |
| Flexor digitorum profundusd | 25–100 | 0.5–2.0 | 1–2 |
| Flexed elbow and pronated forearm | – | – | – |
| Brachioradialisd | 25–100 | 0.5–2.0 | 1–3 |
| Bicepsd | 50–200 | 1.0–4.0 | 2–4 |
| Brachialisd | 25–100 | 0.5–2.0 | 1–2 |
| Pronator quadratusd | 10–50 | 0.2–1.0 | 1 |
| Pronator teresd | 25–75 | 0.5–1.5 | 1–2 |
| If thumb spasticity is presentc | – | – | – |
| Flexor pollicis longus | 10–50 | 0.2–1.0 | 1 |
| Adductor pollicis | 5–30 | 0.1–0.6 | 1 |
| Flexor pollicis brevis or opponens pollicis | 5–30 | 0.1–0.6 | 1 |
MP main period; OLEX open-label extension
aMaximum 1.0 mL per injection site
bInjection of all these muscles is mandatory
cIf muscle is chosen for injection. For muscles not requiring treatment, 0 U/mL might be applicable
d400 U dose distribution at the investigator’s discretion