Table 2.
Between-group behavioral score and demographic comparisons.
| SRS: Social Deficits | SCARED-p: Anxiety | ARI-p: Reactivity | SDQ-Hyperactivity | CBCL-AB: Aggression | CBCL-AP: Attention Problems | CBCL-WD: Depression | Age | Gender (X2) | FSIQ | |
|---|---|---|---|---|---|---|---|---|---|---|
| A. Behavioral data cohort (n=1093) | ||||||||||
| Comparisons between subgroups | ||||||||||
| Emot vs. Attn | 0.07 | 4.21 × 10−3* | 7.30 × 10−30* | 5.43 × 10−4* | 1.85 × 10−29* | 0.053 | 0.15 | 0.014* | 0.32 | 0.13 |
| Emot vs. AnxDep | 0.01* | 1.77 × 10−11* | 3.52 × 10−8 * | 4.58 × 10−14* | 3.80 × 10−17* | 2.03 × 10−5* | 1.43 × 10−6* | 6.80 × 10−6* | 0.76 | 0.25 |
| Attn vs. AnxDep | 0.16 | 2.72 × 10−16* | 4.72 × 10−14* | 1.41 × 10−6* | 8.13 × 10−12* | 1.70 × 10−3* | 5.92 × 10−9* | 0.02* | 0.19 | 0.056 |
| Comparisons to controls | ||||||||||
| Emot | 3.71 × 10−56* | 1.68 × 10−26* | 3.33 × 10−50* | 8.07 × 10−34* | 1.26 × 10−54* | 1.19 × 10−39* | 3.17 × 10−36* | 0.15 | 0.37 | 8.94 × 10−3* |
| Attn | 3.75 × 10−41* | 3.57 × 10−14* | 0.37 | 3.48 × 10−17* | 1.15 × 10−4* | 2.49 × 10−30* | 5.38 × 10−31* | 0.03* | 0.18 | 2.01 × 10−4* |
| AnxDep | 4.92 × 10−27* | 8.92 × 10−34* | 8.47 × 10−17* | 7.51 × 10−4* | 7.58 × 10−19* | 9.30 × 10−14* | 2.68 × 10−34* | 2.69 × 10−6* | 0.64 | 0.13 |
| hSRS (Emot + Attn + AnxDep) | 1.68 × 10−102* | 1.19 × 10−56* | 2.44 × 10−38 * | 5.40 × 10−40* | 1.91 × 10−53* | 2.15 x 10−67* | 4.18 x 10−81* | 7.14 x 10−3* | 0.3 | 7.06 x 10−5* |
| B. Neuroimaging cohort (n = 527; subset of behavioral data cohort) | ||||||||||
| Comparisons between subgroups | ||||||||||
| Emot vs. Attn | 0.09 | 0.49 | 1.81 × 10−14* | 4.01 × 10−3* | 5.95 × 10−15* | 0.35 | 0.24 | 4.49 × 10−3* | 0.76 | 0.21 |
| Emot vs. AnxDep | 0.02* | 3.27 × 10−7* | 2.28 × 10−5* | 2.96 × 10−7* | 1.08 × 10−10* | 4.61 × 10−2* | 3.93 × 10−4* | 4.36 × 10−4* | 0.99 | 0.29 |
| Attn vs. AnxDep | 0.12 | 1.88 × 10−7* | 2.38 × 10−7* | 4.14 × 10−3* | 8.12 × 10−8* | 0.08 | 5.83 × 10−4* | 0.06 | 0.66 | 0.11 |
| Comparisons to controls | ||||||||||
| Emot | 2.41 × 10−26* | 3.03 × 10−9* | 1.93 × 10−23* | 8.93 × 10−17* | 2.05 × 10−26* | 3.19 × 10−18* | 1.23 × 10−15* | 0.09 | 0.31 | 0.04* |
| Attn | 9.22 × 10−20* | 1.26 × 10−8* | 0.31 | 8.18 × 10−9* | 1.15 × 10−3* | 2.19 × 10−15* | 8.80 × 10−17* | 4.93 × 10−3* | 0.12 | 1.86 × 10−3* |
| AnxDep | 4.32 × 10−13* | 5.01 × 10−17* | 1.84 × 10−9* | 2.35 × 10−3* | 3.01 × 10−12* | 1.94 × 10−9* | 2.14 × 10−17* | 5.34 × 10−5* | 0.61 | 0.16 |
| hSRS (Emot + Attn + AnxDep) | 2.33 × 10−47* | 3.10 × 10−25* | 4.53 × 10−19* | 1.75 × 10−20* | 6.96 × 10−29* | 1.09 × 10−33* | 1.15 × 10−38* | 8.25 × 10−3* | 0.07 | 1.15 × 10−3* |
*Significant p-values.
Demographic and behavioral score comparisons, presented as p-values, between autistic traits subgroups, and between each autistic traits subgroup and controls. The top section shows these comparisons in the behavioral cohort (“A. Behavorial data cohort (n = 1093)”, with autistic traits subgroups (i.e. Emot, Attn, AnxDep) compared to each other (under “Comparisons between subgroups”), each autistic traits subgroup compared to controls, and finally a combination of all three autistic traits subgroups (hSRS) compared to controls (under “Comparisons to controls”). The bottom section (B. Neuroimaging cohort (n = 527; subset of behavioral data cohort)) presents the same comparisons in the neuroimaging cohort, which is composed of a subset of subjects from the behavioral cohort with usable structural MRI data. Significant p-values are bolded with a “*” superscript.