Table 2. The reported miRNAs in the T2DM and T1DM and its complications .
| Type of miRNA | Biological importance | Source | Nephropathy | Retinopathy | Cardiovascular disease | Reference |
|
T2DM |
||||||
| miR-21 | Promoting fibroblast Migration and targeting SMAD7 and PTEN | Serum | * | * | * | 57, 82-86 |
| miR-29 | Acting as a tumor suppressor and also engaging in apoptosis | Serum/urine | * | * | * | 57, 87-90 |
| miR-126 | Playing an important role in efferocytosis by targeting ADAM-9 | Plasma/urine | * | * | * | 91-94 |
| miR-200 | Engaging in fibrogenesis through TGF-β signaling | Epithelial cells/ | * | * | * | 95-99 |
| miR-375 | Targeting 3’- phosphoinositide – dependent protein kinase – 1 and regulating Glucose – induced biological response in | Serum/blood | Need more experimental studies | * | * | 100, 101 |
| miR-7 | MiR-7 plays a critical role in the proliferation of adult beta cells by targeting several components of mTOR signaling pathway. | Serum | Need more experimental studies | * | * | 70, 102-104 |
| miR-3666 | By targeting adiponectin play key role in insulin secretion | Serum/peripheral blood | Need more experimental studies | Need more experimental studies | Need more experimental studies | 73 |
| miR-135a | By suppressing Rock‐1 involved in insulin signaling pathway | Serum/plasma | + | Need more experimental studies | Need more experimental studies | 74 |
|
T1DM |
||||||
| miR-326 | mediated TH-17 differentiation through translational inhibition of Ets-1 | Blood | * | Need more experimental studies | Need more experimental studies | 105, 106 |
| miR-146 | By targeting IRAK1 and TRAF6 modulate inflammatory response | PBMCs | * | * | * | 107-110 |